UBQLN4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of UBQLN4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UBQLN4 at tissue level.

III. Associated gene sets

GO_0032434Biological processregulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006281Biological processDNA repair
GO_0006974Biological processDNA damage response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0006914Biological processautophagy
GO_1901097Biological processnegative regulation of autophagosome maturation
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0031410Cellular componentcytoplasmic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0031595Cellular componentnuclear proteasome complex
GO_0090734Cellular componentsite of DNA damage
GO_0005829Cellular componentcytosol
GO_0005776Cellular componentautophagosome
GO_0005737Cellular componentcytoplasm
GO_0031597Cellular componentcytosolic proteasome complex
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0036435Molecular functionK48-linked polyubiquitin modification-dependent protein binding
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBQLN4
Protein nameUbiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75)
SynonymsUBIN
C1orf6
CIP75
DescriptionFUNCTION: Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins . Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain . Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome . MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ) . Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation . Collaborates with DESI1/POST in the export of ubiquitinated proteins from the nucleus to the cytoplasm . Also plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery . Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion . .

AccessionsENST00000368309.4 [Q9NRR5-1]
Q9NRR5