Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 7 studies | 25% ± 7% | |
endothelial cell | 6 studies | 23% ± 7% | |
epithelial cell | 6 studies | 31% ± 11% | |
macrophage | 6 studies | 19% ± 3% | |
microglial cell | 4 studies | 19% ± 4% | |
astrocyte | 4 studies | 29% ± 9% | |
oligodendrocyte precursor cell | 4 studies | 32% ± 10% | |
classical monocyte | 3 studies | 20% ± 2% | |
neuron | 3 studies | 17% ± 0% | |
myeloid cell | 3 studies | 20% ± 1% | |
lymphocyte | 3 studies | 22% ± 4% | |
GABAergic neuron | 3 studies | 38% ± 16% | |
glutamatergic neuron | 3 studies | 43% ± 20% | |
dendritic cell | 3 studies | 23% ± 4% | |
monocyte | 3 studies | 18% ± 1% | |
basal cell | 3 studies | 23% ± 8% | |
interneuron | 3 studies | 43% ± 18% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2001.39 | 1443 / 1445 | 100% | 27.90 | 183 / 183 |
stomach | 100% | 2018.04 | 359 / 359 | 98% | 22.77 | 281 / 286 |
intestine | 100% | 2271.41 | 966 / 966 | 98% | 17.51 | 515 / 527 |
lung | 100% | 2051.16 | 577 / 578 | 98% | 20.24 | 1130 / 1155 |
ovary | 100% | 2459.36 | 180 / 180 | 94% | 14.07 | 406 / 430 |
breast | 100% | 2320.17 | 459 / 459 | 93% | 22.09 | 1040 / 1118 |
skin | 100% | 2907.33 | 1809 / 1809 | 92% | 19.48 | 435 / 472 |
brain | 95% | 1585.71 | 2507 / 2642 | 97% | 24.26 | 683 / 705 |
pancreas | 100% | 1903.46 | 327 / 328 | 92% | 13.90 | 163 / 178 |
kidney | 100% | 1173.80 | 89 / 89 | 90% | 18.40 | 811 / 901 |
bladder | 100% | 2040.00 | 21 / 21 | 87% | 13.01 | 439 / 504 |
prostate | 100% | 1925.36 | 245 / 245 | 86% | 17.49 | 433 / 502 |
thymus | 100% | 2447.17 | 652 / 653 | 84% | 13.08 | 511 / 605 |
uterus | 100% | 2531.54 | 170 / 170 | 78% | 9.92 | 358 / 459 |
adrenal gland | 100% | 1913.80 | 258 / 258 | 66% | 8.32 | 151 / 230 |
liver | 99% | 1197.82 | 224 / 226 | 65% | 8.02 | 265 / 406 |
adipose | 100% | 2220.78 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2107.69 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2382.07 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2236.01 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 95% | 1520.86 | 814 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 91% | 1667.72 | 841 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 84% | 10.60 | 67 / 80 |
tonsil | 0% | 0 | 0 / 0 | 78% | 9.15 | 35 / 45 |
lymph node | 0% | 0 | 0 / 0 | 55% | 11.91 | 16 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0000209 | Biological process | protein polyubiquitination |
GO_0036503 | Biological process | ERAD pathway |
GO_0000151 | Cellular component | ubiquitin ligase complex |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0034450 | Molecular function | ubiquitin-ubiquitin ligase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | UBE4A |
Protein name | Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A) Ubiquitin conjugation factor E4 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4) Alternative protein UBE4A |
Synonyms | KIAA0126 |
Description | FUNCTION: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. . FUNCTION: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. .; FUNCTION: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. . FUNCTION: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. . |
Accessions | ENST00000431736.6 [Q14139-2] L8E7Q1 B7Z7P0 ENST00000545354.1 Q05BZ7 Q14139 ENST00000252108.8 [Q14139-1] |