UBASH3B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051279Biological processregulation of release of sequestered calcium ion into cytosol
GO_0038063Biological processcollagen-activated tyrosine kinase receptor signaling pathway
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0035335Biological processpeptidyl-tyrosine dephosphorylation
GO_0090331Biological processnegative regulation of platelet aggregation
GO_0070527Biological processplatelet aggregation
GO_0045779Biological processnegative regulation of bone resorption
GO_0009968Biological processnegative regulation of signal transduction
GO_0045670Biological processregulation of osteoclast differentiation
GO_0045671Biological processnegative regulation of osteoclast differentiation
GO_0005634Cellular componentnucleus
GO_0005737Cellular componentcytoplasm
GO_0051219Molecular functionphosphoprotein binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene nameUBASH3B
Protein nameUbiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)
SynonymsSTS1
KIAA1959
DescriptionFUNCTION: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. .

AccessionsQ8TF42
ENST00000284273.6