UBASH3A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of UBASH3A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UBASH3A at tissue level.

III. Associated gene sets

GO_0001817Biological processregulation of cytokine production
GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0016607Cellular componentnuclear speck
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBASH3A
Protein nameUbiquitin associated and SH3 domain containing A (Ubiquitin associated and SH3 domain containing, A, isoform CRA_c)
Ubiquitin associated and SH3 domain containing A
Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1)
SynonymsSTS2
hCG_401269
DescriptionFUNCTION: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligible protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. .

AccessionsENST00000634718.1
A0A0U1RQY9
P57075
A0A0U1RRC9
ENST00000635189.1
A0A0U1RQL4
ENST00000635108.1
ENST00000291535.11 [P57075-2]
A0A0U1RR03
A0A0U1RR38
ENST00000635325.1
ENST00000319294.11 [P57075-1]
ENST00000473381.1
ENST00000398367.1 [P57075-3]