UAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006048Biological processUDP-N-acetylglucosamine biosynthetic process
GO_0032481Biological processpositive regulation of type I interferon production
GO_0140374Biological processantiviral innate immune response
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0141090Molecular functionprotein serine pyrophosphorylase activity
GO_0052630Molecular functionUDP-N-acetylgalactosamine diphosphorylase activity
GO_0042802Molecular functionidentical protein binding
GO_0003977Molecular functionUDP-N-acetylglucosamine diphosphorylase activity

IV. Literature review

[source]
Gene nameUAP1
Protein nameUDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Protein-pyrophosphorylation enzyme) (EC 2.7.4.-) (Sperm-associated antigen 2) (UDP-N-acetylgalactosamine pyrophosphorylase) (EC 2.7.7.83) (UDP-N-acetylglucosamine pyrophosphorylase) (EC 2.7.7.23)
SynonymsSPAG2
DescriptionFUNCTION: Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide . Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) . In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses . .; FUNCTION: [Isoform AGX1]: Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P). .; FUNCTION: [Isoform AGX1]: Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P). .

AccessionsQ16222
ENST00000367925.6 [Q16222-1]
ENST00000367926.9 [Q16222-2]