Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 24% ± 5% | |
| oligodendrocyte | 6 studies | 27% ± 13% | |
| glutamatergic neuron | 5 studies | 38% ± 23% | |
| microglial cell | 5 studies | 27% ± 15% | |
| GABAergic neuron | 4 studies | 33% ± 15% | |
| astrocyte | 4 studies | 39% ± 19% | |
| adipocyte | 3 studies | 19% ± 4% | |
| macrophage | 3 studies | 21% ± 2% | |
| type I pneumocyte | 3 studies | 23% ± 5% | |
| interneuron | 3 studies | 47% ± 19% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 6 studies | 35% ± 18% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 369.89 | 245 / 245 | 98% | 5.82 | 494 / 502 |
| esophagus | 100% | 202.01 | 1444 / 1445 | 97% | 3.96 | 178 / 183 |
| breast | 100% | 333.78 | 459 / 459 | 97% | 4.85 | 1086 / 1118 |
| brain | 98% | 186.36 | 2584 / 2642 | 99% | 4.39 | 698 / 705 |
| thymus | 100% | 331.06 | 653 / 653 | 96% | 4.10 | 583 / 605 |
| uterus | 100% | 355.10 | 170 / 170 | 95% | 3.96 | 436 / 459 |
| ovary | 100% | 429.17 | 180 / 180 | 94% | 3.48 | 404 / 430 |
| lung | 100% | 226.79 | 576 / 578 | 92% | 3.69 | 1065 / 1155 |
| stomach | 99% | 164.89 | 355 / 359 | 93% | 3.77 | 265 / 286 |
| skin | 99% | 303.36 | 1799 / 1809 | 91% | 4.84 | 429 / 472 |
| intestine | 100% | 236.96 | 965 / 966 | 90% | 3.35 | 473 / 527 |
| pancreas | 97% | 148.45 | 319 / 328 | 92% | 3.08 | 164 / 178 |
| bladder | 100% | 354.05 | 21 / 21 | 89% | 3.08 | 450 / 504 |
| kidney | 100% | 203.38 | 89 / 89 | 87% | 3.30 | 781 / 901 |
| adrenal gland | 100% | 233.61 | 257 / 258 | 86% | 3.20 | 197 / 230 |
| liver | 100% | 206.02 | 225 / 226 | 74% | 2.60 | 300 / 406 |
| muscle | 100% | 260.68 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 212.97 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 224.75 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 296.86 | 1200 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 2.80 | 27 / 29 |
| heart | 92% | 128.73 | 796 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 84% | 2.79 | 38 / 45 |
| peripheral blood | 68% | 103.14 | 636 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 51% | 1.51 | 41 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0031591 | Biological process | wybutosine biosynthetic process |
| GO_0010181 | Molecular function | FMN binding |
| GO_0102521 | Molecular function | tRNA-4-demethylwyosine synthase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0051539 | Molecular function | 4 iron, 4 sulfur cluster binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | TYW1B |
| Protein name | tRNA-yW synthesizing protein 1 homolog B S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 2) (tRNA wybutosine-synthesizing protein 1 homolog B) |
| Synonyms | RSAFD2 |
| Description | FUNCTION: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity). . |
| Accessions | A0A087X1V1 ENST00000612372.4 ENST00000620995.5 [Q6NUM6-1] ENST00000610600.1 Q6NUM6 A0A087WWV6 |
