TYRP1 | OmnibusX

Name	Number of supported studies	Average coverage
melanocyte	6 studies	68% ± 21%	Explore
retinal pigment epithelial cell	5 studies	72% ± 18%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of TYRP1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	71%	3479.91	1291 / 1809	74%	733.45	349 / 472
lung	86%	328.02	498 / 578	48%	1.95	556 / 1155
eye	0%	0	0 / 0	100%	3511.64	80 / 80
heart	93%	1276.37	804 / 861	0%	0	0 / 0
kidney	62%	216.36	55 / 89	5%	0.41	46 / 901
esophagus	6%	15.17	82 / 1445	51%	1.88	94 / 183
stomach	15%	31.52	54 / 359	41%	2.45	116 / 286
intestine	14%	48.97	140 / 966	29%	0.83	153 / 527
ovary	0%	0	0 / 180	30%	1.20	130 / 430
muscle	28%	79.65	223 / 803	0%	0	0 / 0
bladder	0%	0	0 / 21	24%	0.56	123 / 504
pancreas	0%	0	0 / 328	24%	0.86	43 / 178
breast	3%	12.66	16 / 459	19%	1.96	213 / 1118
brain	12%	28.09	330 / 2642	7%	0.23	46 / 705
blood vessel	19%	38.34	250 / 1335	0%	0	0 / 0
prostate	2%	3.81	5 / 245	16%	0.66	81 / 502
uterus	0%	0	0 / 170	12%	5.71	53 / 459
liver	0%	1.27	1 / 226	11%	0.56	44 / 406
thymus	0%	0	0 / 653	8%	0.52	46 / 605
tonsil	0%	0	0 / 0	7%	0.23	3 / 45
adrenal gland	0%	0	0 / 258	7%	1.14	15 / 230
lymph node	0%	0	0 / 0	3%	0.04	1 / 29
adipose	2%	10.32	23 / 1204	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0043438	Biological process	acetoacetic acid metabolic process
GO_0030318	Biological process	melanocyte differentiation
GO_0042438	Biological process	melanin biosynthetic process
GO_0032438	Biological process	melanosome organization
GO_0048023	Biological process	positive regulation of melanin biosynthetic process
GO_0010008	Cellular component	endosome membrane
GO_0033162	Cellular component	melanosome membrane
GO_0030669	Cellular component	clathrin-coated endocytic vesicle membrane
GO_0042470	Cellular component	melanosome
GO_0097708	Cellular component	intracellular vesicle
GO_0005737	Cellular component	cytoplasm
GO_0042803	Molecular function	protein homodimerization activity
GO_0016491	Molecular function	oxidoreductase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding
GO_0004503	Molecular function	tyrosinase activity

Gene name	TYRP1
Protein name	5,6-dihydroxyindole-2-carboxylic acid oxidase (DHICA oxidase) (EC 1.14.18.-) (Catalase B) (Glycoprotein 75) (Melanoma antigen gp75) (Tyrosinase-related protein 1) (TRP) (TRP-1) (TRP1) Tyrosinase related protein 1 5,6-dihydroxyindole-2-carboxylic acid oxidase (Tyrosinase-related protein 1)
Synonyms	CAS2 TYRRP TYRP
Description	FUNCTION: Plays a role in melanin biosynthesis . Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) . May regulate or influence the type of melanin synthesized . Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity). .
Accessions	ENST00000388918.10 ENST00000381136.2 E7EQI3 C9JZ52 ENST00000473763.1 P17643 Q6LES1

TYRP1 report