TYR | OmnibusX

Name	Number of supported studies	Average coverage
melanocyte	5 studies	64% ± 23%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of TYR at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	71%	505.42	1284 / 1809	88%	1116.43	417 / 472
eye	0%	0	0 / 0	100%	679.41	80 / 80
breast	2%	2.58	10 / 459	0%	0	0 / 1118
prostate	1%	0.75	2 / 245	0%	0	0 / 502
adipose	0%	0.87	6 / 1204	0%	0	0 / 0
blood vessel	0%	0.58	4 / 1335	0%	0	0 / 0
uterus	0%	0	0 / 170	0%	0.58	1 / 459
esophagus	0%	0.46	3 / 1445	0%	0	0 / 183
brain	0%	0.19	5 / 2642	0%	0	0 / 705
lung	0%	0.12	1 / 578	0%	0	0 / 1155
muscle	0%	0.11	1 / 803	0%	0	0 / 0
kidney	0%	0	0 / 89	0%	0.09	1 / 901
intestine	0%	0.14	1 / 966	0%	0	0 / 527
abdomen	0%	0	0 / 0	0%	0	0 / 0
adrenal gland	0%	0	0 / 258	0%	0	0 / 230
bladder	0%	0	0 / 21	0%	0	0 / 504
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
liver	0%	0	0 / 226	0%	0	0 / 406
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
ovary	0%	0	0 / 180	0%	0	0 / 430
pancreas	0%	0	0 / 328	0%	0	0 / 178
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
stomach	0%	0	0 / 359	0%	0	0 / 286
thymus	0%	0	0 / 653	0%	0	0 / 605
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007601	Biological process	visual perception
GO_0008283	Biological process	cell population proliferation
GO_0033280	Biological process	response to vitamin D
GO_0006583	Biological process	melanin biosynthetic process from tyrosine
GO_0042438	Biological process	melanin biosynthetic process
GO_0009411	Biological process	response to UV
GO_0051591	Biological process	response to cAMP
GO_0043473	Biological process	pigmentation
GO_0048538	Biological process	thymus development
GO_0009637	Biological process	response to blue light
GO_0006726	Biological process	eye pigment biosynthetic process
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005764	Cellular component	lysosome
GO_0033162	Cellular component	melanosome membrane
GO_0005737	Cellular component	cytoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005798	Cellular component	Golgi-associated vesicle
GO_0042470	Cellular component	melanosome
GO_0042803	Molecular function	protein homodimerization activity
GO_0004503	Molecular function	tyrosinase activity
GO_0042802	Molecular function	identical protein binding
GO_0005507	Molecular function	copper ion binding
GO_0005515	Molecular function	protein binding

Gene name	TYR
Protein name	TYR protein Tyrosinase (EC 1.14.18.1) (LB24-AB) (Monophenol monooxygenase) (SK29-AB) (Tumor rejection antigen AB) Tyrosinase (EC 1.14.18.1) (Monophenol monooxygenase)
Synonyms	hCG_19690
Description	FUNCTION: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone . .
Accessions	ENST00000263321.6 [P14679-1] Q9UMA2 A0A024DBG7 L8B0B9 L8B086 P14679 U3M8N0 L8B082 U3M9D5 U3M9J2

TYR report