TUSC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015693Biological processmagnesium ion transport
GO_0050890Biological processcognition
GO_0018279Biological processprotein N-linked glycosylation via asparagine
GO_0006487Biological processprotein N-linked glycosylation
GO_1903830Biological processmagnesium ion transmembrane transport
GO_0055085Biological processtransmembrane transport
GO_0008250Cellular componentoligosaccharyltransferase complex
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0015095Molecular functionmagnesium ion transmembrane transporter activity

IV. Literature review

[source]
Gene nameTUSC3
Protein nameTumor suppressor candidate 3
Tumor suppressor candidate 3 isoform b
Tumor suppressor candidate 3 isoform a
Tumor suppressor candidate 3 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3) (Oligosaccharyl transferase subunit TUSC3) (Magnesium uptake/transporter TUSC3) (Protein N33)
SynonymsN33
DescriptionFUNCTION: Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. .; FUNCTION: Magnesium transporter. .

AccessionsA0A0A0MTC2
D6RDV0
Q6QQE4
ENST00000382020.8 [Q13454-2]
Q6Q320
ENST00000509380.5
ENST00000503731.6 [Q13454-1]
Q6Q319
ENST00000510836.5
ENST00000506802.5
Q13454
D6RIY7
ENST00000515859.5
ENST00000511783.2
D6RA37