TTLL8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TTLL8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TTLL8 at tissue level.

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0003341Biological processcilium movement
GO_0018094Biological processprotein polyglycylation
GO_0030317Biological processflagellated sperm motility
GO_0005930Cellular componentaxoneme
GO_0005929Cellular componentcilium
GO_0005829Cellular componentcytosol
GO_0036126Cellular componentsperm flagellum
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005874Cellular componentmicrotubule
GO_0070736Molecular functionprotein-glycine ligase activity, initiating
GO_0070735Molecular functionprotein-glycine ligase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameTTLL8
Protein nameProtein monoglycylase TTLL8 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 8)
Tubulin tyrosine ligase like 8
Synonyms
DescriptionFUNCTION: Monoglycylase which modifies both tubulin and non-tubulin proteins, adding a single glycine to the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of target proteins. Not involved in elongation step of the polyglycylation reaction. Preferentially monoglycylates alpha-tubulin over beta-tubulin. Together with TTLL3, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance. Together with TTLL3, glycylates sperm flagella which regulates axonemal dynein motor activity, thereby controlling flagellar beat, directional sperm swimming and male fertility. Monoglycylates non-tubulin proteins such as ANP32A, ANP32B, SET, NCL and NAP1. .

AccessionsENST00000433387.2
A0A1C7CYW9
A6PVC2