I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 5 studies | 18% ± 2% | |
| astrocyte | 5 studies | 24% ± 11% | |
| endothelial cell | 3 studies | 25% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 5 studies | 18% ± 2% | |
| astrocyte | 5 studies | 24% ± 11% | |
| endothelial cell | 3 studies | 25% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 21% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 9744.78 | 653 / 653 | 97% | 5.12 | 586 / 605 |
| brain | 96% | 3677.06 | 2529 / 2642 | 99% | 6.71 | 697 / 705 |
| esophagus | 100% | 6144.83 | 1440 / 1445 | 95% | 3.28 | 173 / 183 |
| bladder | 100% | 8668.81 | 21 / 21 | 94% | 5.09 | 472 / 504 |
| adrenal gland | 100% | 6456.20 | 258 / 258 | 93% | 3.34 | 215 / 230 |
| breast | 100% | 8575.03 | 459 / 459 | 93% | 4.16 | 1044 / 1118 |
| intestine | 100% | 7703.31 | 966 / 966 | 93% | 4.03 | 490 / 527 |
| prostate | 100% | 12495.42 | 245 / 245 | 92% | 3.61 | 463 / 502 |
| pancreas | 96% | 2952.41 | 316 / 328 | 96% | 5.22 | 170 / 178 |
| uterus | 100% | 12567.25 | 170 / 170 | 90% | 3.68 | 413 / 459 |
| ovary | 100% | 17726.96 | 180 / 180 | 90% | 4.12 | 385 / 430 |
| stomach | 99% | 4568.69 | 356 / 359 | 90% | 3.29 | 258 / 286 |
| lung | 100% | 7515.67 | 578 / 578 | 87% | 3.56 | 1009 / 1155 |
| skin | 99% | 6182.66 | 1788 / 1809 | 86% | 3.52 | 405 / 472 |
| kidney | 100% | 6802.93 | 89 / 89 | 82% | 4.98 | 743 / 901 |
| liver | 60% | 1174.17 | 135 / 226 | 46% | 1.25 | 186 / 406 |
| adipose | 100% | 8561.66 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 7.88 | 29 / 29 |
| spleen | 100% | 9414.67 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.28 | 1 / 1 |
| blood vessel | 100% | 5833.01 | 1330 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 6814.77 | 917 / 929 | 0% | 0 | 0 / 0 |
| heart | 93% | 3853.87 | 797 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 73% | 1.99 | 33 / 45 |
| eye | 0% | 0 | 0 / 0 | 63% | 1.79 | 50 / 80 |
| muscle | 55% | 1263.55 | 439 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0060271 | Biological process | cilium assembly |
| GO_0003341 | Biological process | cilium movement |
| GO_0018094 | Biological process | protein polyglycylation |
| GO_0030317 | Biological process | flagellated sperm motility |
| GO_0035082 | Biological process | axoneme assembly |
| GO_0005930 | Cellular component | axoneme |
| GO_0005929 | Cellular component | cilium |
| GO_0005829 | Cellular component | cytosol |
| GO_0036126 | Cellular component | sperm flagellum |
| GO_0015630 | Cellular component | microtubule cytoskeleton |
| GO_0005874 | Cellular component | microtubule |
| GO_0070736 | Molecular function | protein-glycine ligase activity, initiating |
| GO_0070735 | Molecular function | protein-glycine ligase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | TTLL3 |
| Protein name | Tubulin monoglycylase TTLL3 (EC 6.3.2.-) (HOTTL) (Tubulin--tyrosine ligase-like protein 3) Tubulin monoglycylase TTLL3 Tubulin tyrosine ligase like 3 |
| Synonyms | PRO0207 |
| Description | FUNCTION: Monoglycylase which modifies alpha- and beta-tubulin, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of tubulin. Not involved in elongation step of the polyglycylation reaction (By similarity). Preferentially glycylates a beta-tail peptide over the alpha-tail, although shifts its preference toward alpha-tail as beta-tail glutamylation increases (By similarity). Competes with polyglutamylases for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (By similarity). Together with TTLL8, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance (By similarity). Involved in microtubule glycylation of primary cilia in colon which controls cell proliferation of epithelial cells and plays an essential role in colon cancer development . Together with TTLL8, glycylates sperm flagella which regulates axonemal dynein motor activity, thereby controlling flagellar beat, directional sperm swimming and male fertility (By similarity). . |
| Accessions | ENST00000427220.5 C9JZ73 C9IZU0 A0A8I5KXU2 R4GN12 H7C197 ENST00000455274.5 C9JUK0 H3BLT7 C9JNK7 ENST00000438141.5 [Q9Y4R7-2] C9JNK2 ENST00000703870.1 ENST00000473661.5 F8WD18 C9JQ30 ENST00000426895 ENST00000685419.1 C9JKU2 ENST00000452597.5 H7C0T5 ENST00000430390.5 ENST00000430718.5 J3KQB2 ENST00000431204.5 ENST00000426827.5 ENST00000383827.5 [Q9Y4R7-2] ENST00000417065.5 C9JRM2 ENST00000414814.5 ENST00000496246.5 A0A994J3Y4 ENST00000310252.11 Q9Y4R7 ENST00000422738.5 E5RGZ6 ENST00000419081.5 R4GMR7 R4GMW2 ENST00000430793.1 [Q9Y4R7-5] ENST00000426895.10 [Q9Y4R7-1] ENST00000452823.5 H0Y5E3 ENST00000418745.5 ENST00000439814.5 C9JSD3 C9JWZ9 C9JW59 ENST00000443148.5 ENST00000438596.5 ENST00000471058.1 F8WBP6 ENST00000474948.5 |
