TTK | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of TTK at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	97%	652.70	1758 / 1809	85%	9.49	402 / 472
stomach	71%	139.86	254 / 359	94%	16.02	268 / 286
intestine	53%	151.59	514 / 966	95%	15.58	499 / 527
lung	60%	74.58	345 / 578	85%	14.20	977 / 1155
esophagus	42%	247.71	611 / 1445	99%	22.12	182 / 183
breast	44%	33.36	202 / 459	88%	13.37	988 / 1118
bladder	19%	12.90	4 / 21	93%	16.13	469 / 504
ovary	13%	16.18	23 / 180	98%	17.42	422 / 430
uterus	11%	11.37	18 / 170	98%	22.85	450 / 459
tonsil	0%	0	0 / 0	100%	23.81	45 / 45
spleen	95%	208.87	230 / 241	0%	0	0 / 0
adrenal gland	71%	114.14	182 / 258	21%	2.34	49 / 230
lymph node	0%	0	0 / 0	90%	11.63	26 / 29
prostate	48%	37.24	117 / 245	35%	2.36	178 / 502
pancreas	11%	7.16	36 / 328	58%	4.40	103 / 178
thymus	39%	26.49	254 / 653	15%	5.38	93 / 605
liver	14%	23.26	32 / 226	39%	3.12	158 / 406
peripheral blood	52%	625.42	481 / 929	0%	0	0 / 0
brain	3%	1.96	88 / 2642	39%	4.26	278 / 705
kidney	20%	24.58	18 / 89	11%	0.76	98 / 901
adipose	25%	22.24	302 / 1204	0%	0	0 / 0
blood vessel	13%	9.11	169 / 1335	0%	0	0 / 0
heart	6%	5.26	55 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	5%	0.19	4 / 80
muscle	1%	0.73	6 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0018105	Biological process	peptidyl-serine phosphorylation
GO_0007059	Biological process	chromosome segregation
GO_0007052	Biological process	mitotic spindle organization
GO_0034501	Biological process	protein localization to kinetochore
GO_0016321	Biological process	female meiosis chromosome segregation
GO_0033316	Biological process	meiotic spindle assembly checkpoint signaling
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_1903096	Biological process	protein localization to meiotic spindle midzone
GO_0007094	Biological process	mitotic spindle assembly checkpoint signaling
GO_0007051	Biological process	spindle organization
GO_0016020	Cellular component	membrane
GO_0000776	Cellular component	kinetochore
GO_0005737	Cellular component	cytoplasm
GO_0005819	Cellular component	spindle
GO_0005634	Cellular component	nucleus
GO_0004712	Molecular function	protein serine/threonine/tyrosine kinase activity
GO_0106310	Molecular function	protein serine kinase activity
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0042802	Molecular function	identical protein binding
GO_0043515	Molecular function	kinetochore binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

Gene name	TTK
Protein name	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT) TTK protein kinase
Synonyms	MPS1 MPS1L1
Description	FUNCTION: Phosphorylates proteins on serine, threonine, and tyrosine . Probably associated with cell proliferation . Phosphorylates MAD1L1 to promote mitotic checkpoint signaling . Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint . .
Accessions	ENST00000509894.5 [P33981-2] D6REX1 ENST00000504040.1 ENST00000509313.5 ENST00000369798.7 [P33981-1] ENST00000502580.5 ENST00000511260.5 D6RIC6 P33981 ENST00000627129.1 D6RFY1 ENST00000230510.7 [P33981-2] D6RF82

TTK report