TTI1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000003Biological processpositive regulation of DNA damage checkpoint
GO_0032006Biological processregulation of TOR signaling
GO_0050821Biological processprotein stabilization
GO_0031932Cellular componentTORC2 complex
GO_0031931Cellular componentTORC1 complex
GO_0110078Cellular componentTTT Hsp90 cochaperone complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTTI1
Protein nameTELO2-interacting protein 1 homolog (Protein SMG10)
TELO2 interacting protein 1
SynonymsSMG10
KIAA0406
DescriptionFUNCTION: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. .

AccessionsENST00000620381.1
ENST00000449821.1
ENST00000373448.6
O43156
ENST00000373447.8
A0A087WT32