TSSK2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TSSK2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TSSK2 at tissue level.

III. Associated gene sets

GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0007286Biological processspermatid development
GO_0005814Cellular componentcentriole
GO_0001669Cellular componentacrosomal vesicle
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0044877Molecular functionprotein-containing complex binding
GO_0005524Molecular functionATP binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene nameTSSK2
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (DiGeorge syndrome protein G) (DGS-G) (Serine/threonine-protein kinase 22B)
SynonymsDGSG
SPOGA2
STK22B
hCG_1641087
DescriptionFUNCTION: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. .

AccessionsENST00000399635.4
A0ZT99
Q96PF2