TRPM5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRPM5 at tissue level.

III. Associated gene sets

GO_0035725Biological processsodium ion transmembrane transport
GO_0019722Biological processcalcium-mediated signaling
GO_0071805Biological processpotassium ion transmembrane transport
GO_0070588Biological processcalcium ion transmembrane transport
GO_0034702Cellular componentmonoatomic ion channel complex
GO_0043025Cellular componentneuronal cell body
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0030425Cellular componentdendrite
GO_0099604Molecular functionligand-gated calcium channel activity
GO_0005267Molecular functionpotassium channel activity
GO_0005272Molecular functionsodium channel activity
GO_0005216Molecular functionmonoatomic ion channel activity
GO_0005515Molecular functionprotein binding
GO_0005227Molecular functioncalcium-activated cation channel activity

IV. Literature review

[source]
Gene nameTRPM5
Protein nameTransient receptor potential cation channel subfamily M member 5
TRPM5 protein
Transient receptor potential cation channel subfamily M member 5 (Long transient receptor potential channel 5) (LTrpC-5) (LTrpC5) (MLSN1- and TRP-related gene 1 protein)
SynonymsMTR1
LTRPC5
DescriptionFUNCTION: Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals. .

AccessionsENST00000696290.1 [Q9NZQ8-1]
E9PRW0
ENST00000533060.5
A0A0C4DGF4
Q9NZQ8
B7ZKS6
B7ZKS5
E9PQF7
ENST00000528453.1
ENST00000533881.5