TRMT61B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090646Biological processmitochondrial tRNA processing
GO_0030488Biological processtRNA methylation
GO_0006397Biological processmRNA processing
GO_0031167Biological processrRNA methylation
GO_0031515Cellular componenttRNA (m1A) methyltransferase complex
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0016433Molecular functionrRNA (adenine) methyltransferase activity
GO_0061953Molecular functionmRNA (adenine-N1-)-methyltransferase activity
GO_0160107Molecular functiontRNA (adenine(58)-N1)-methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRMT61B
Protein nametRNA (adenine(58)-N(1))-methyltransferase (EC 2.1.1.220)
tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-)
Synonyms
DescriptionFUNCTION: Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) . Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function . In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation . .

AccessionsH7C2E8
ENST00000306108.10
ENST00000419999.5
Q9BVS5
F8WDR2
ENST00000439947.1