TRMT2B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRMT2B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRMT2B at tissue level.

III. Associated gene sets

GO_0008033Biological processtRNA processing
GO_0031167Biological processrRNA methylation
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0030697Molecular functiontRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent
GO_0070041Molecular functionrRNA (uridine-C5-)-methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRMT2B
Protein nametRNA (uracil-5-)-methyltransferase homolog B (EC 2.1.1.35) (TRM2 homolog B) (rRNA (uracil-5-)-methyltransferase TRMT2B) (EC 2.1.1.-)
SynonymsCXorf34
DescriptionFUNCTION: Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and 12S rRNA . Catalyzes the methylation of uridine at position 54 (m5U54) in all tRNAs . Specifically methylates the uridine in position 429 of 12S rRNA (m5U429) . Does not affect RNA stability or mitochondrial translation . .

AccessionsENST00000372935.5 [Q96GJ1-1]
ENST00000372939.5 [Q96GJ1-3]
Q96GJ1
ENST00000372936.4 [Q96GJ1-1]
ENST00000545398.5 [Q96GJ1-1]