TRMT12 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRMT12 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRMT12 at tissue level.

III. Associated gene sets

GO_0031591Biological processwybutosine biosynthetic process
GO_0030488Biological processtRNA methylation
GO_0005737Cellular componentcytoplasm
GO_0008175Molecular functiontRNA methyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0102522Molecular functiontRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity

IV. Literature review

[source]
Gene nameTRMT12
Protein nametRNA methyltransferase 12 homolog
tRNA wybutosine-synthesizing protein 2 homolog (tRNA-yW-synthesizing protein 2) (EC 2.5.1.114) (tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase)
SynonymsTRM12
TYW2
DescriptionFUNCTION: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. .

AccessionsENST00000522518.1
E5RHH6
ENST00000328599.4
Q53H54