TRIM71 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRIM71 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM71 at tissue level.

III. Associated gene sets

GO_2000177Biological processregulation of neural precursor cell proliferation
GO_0035196Biological processmiRNA processing
GO_0000209Biological processprotein polyubiquitination
GO_0035278Biological processmiRNA-mediated gene silencing by inhibition of translation
GO_0051865Biological processprotein autoubiquitination
GO_0010608Biological processpost-transcriptional regulation of gene expression
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_0001843Biological processneural tube closure
GO_0021915Biological processneural tube development
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0017148Biological processnegative regulation of translation
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_2000637Biological processpositive regulation of miRNA-mediated gene silencing
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0072089Biological processstem cell proliferation
GO_0000932Cellular componentP-body
GO_0030371Molecular functiontranslation repressor activity
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM71
Protein nameE3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
SynonymsLIN41
DescriptionFUNCTION: E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism . Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression . .

AccessionsENST00000383763.6
Q2Q1W2
ENST00000707739.1