TRIM60 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRIM60 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM60 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0140082Molecular functionSUMO-ubiquitin ligase activity
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTRIM60
Protein nameTripartite motif containing 60
Tripartite motif-containing protein 60 (RING finger protein 129) (RING finger protein 33)
SynonymsRNF129
RNF33
DescriptionFUNCTION: E3 SUMO-protein ligase that mediates SUMOylation of TAB2 leading to inhibition of NF-kappa-B and MAPK pathways by suppressing the TRAF6/TAB2/TAK1 complex. .

AccessionsD6RAS2
Q495X7
ENST00000341062.6
ENST00000507119.1
ENST00000512596.6
ENST00000647760.1
ENST00000508504.1