TRIM50 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRIM50 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM50 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTRIM50
Protein nameE3 ubiquitin-protein ligase TRIM50 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM50) (Tripartite motif-containing protein 50)
HCG1642804, isoform CRA_c (TRIM50 protein)
SynonymsTRIM50A
hCG_1642804
DescriptionFUNCTION: E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1 . In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction . Promotes also NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (By similarity). .

AccessionsENST00000453152.1 [Q86XT4-1]
B7ZLG2
ENST00000333149.7 [Q86XT4-1]
Q86XT4