TRIM41 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	3 studies	24% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM41 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2395.97	1445 / 1445	100%	7.08	183 / 183
skin	100%	2648.50	1809 / 1809	100%	9.07	472 / 472
thymus	100%	4351.40	653 / 653	100%	12.80	605 / 605
uterus	100%	2382.19	170 / 170	100%	8.87	459 / 459
brain	100%	5180.17	2641 / 2642	100%	15.24	705 / 705
bladder	100%	2589.24	21 / 21	100%	7.78	503 / 504
prostate	100%	2765.00	245 / 245	100%	8.58	501 / 502
intestine	100%	2465.19	966 / 966	100%	7.58	525 / 527
adrenal gland	100%	3062.03	258 / 258	100%	9.17	229 / 230
kidney	100%	2938.02	89 / 89	100%	9.34	897 / 901
liver	100%	2275.52	226 / 226	100%	6.75	404 / 406
pancreas	99%	1825.97	326 / 328	100%	9.02	178 / 178
ovary	100%	2199.66	180 / 180	99%	8.40	427 / 430
breast	100%	2215.12	459 / 459	99%	8.92	1110 / 1118
stomach	100%	2271.61	359 / 359	99%	6.45	282 / 286
lung	100%	2511.27	576 / 578	99%	7.51	1139 / 1155
adipose	100%	2113.92	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	11.69	29 / 29
muscle	100%	2848.23	803 / 803	0%	0	0 / 0
spleen	100%	3702.13	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	9.68	45 / 45
ureter	0%	0	0 / 0	100%	5.45	1 / 1
blood vessel	100%	2159.45	1332 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	7.27	79 / 80
heart	98%	1730.96	845 / 861	0%	0	0 / 0
peripheral blood	96%	1949.77	890 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0051607	Biological process	defense response to virus
GO_0016567	Biological process	protein ubiquitination
GO_0071225	Biological process	cellular response to muramyl dipeptide
GO_0006513	Biological process	protein monoubiquitination
GO_0060340	Biological process	positive regulation of type I interferon-mediated signaling pathway
GO_0005730	Cellular component	nucleolus
GO_0016604	Cellular component	nuclear body
GO_0005737	Cellular component	cytoplasm
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding

Gene name	TRIM41
Protein name	TRIM41 protein E3 ubiquitin-protein ligase TRIM41 (EC 2.3.2.27) (RING finger-interacting protein with C kinase) (RINCK) (Tripartite motif-containing protein 41) Tripartite motif containing 41
Synonyms	RINCK
Description	FUNCTION: E3 ligase that plays essential roles in innate antiviral response . Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections . Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS . Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response . .
Accessions	ENST00000503114.1 ENST00000315073.10 [Q8WV44-1] ENST00000515499.5 H0Y9T3 ENST00000514219.1 D6REK2 Q8WV44 ENST00000351937.9 [Q8WV44-2] A1A4S2 H0YAD6

TRIM41 report