TRIM17 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRIM17 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM17 at tissue level.

III. Associated gene sets

GO_0032880Biological processregulation of protein localization
GO_0016567Biological processprotein ubiquitination
GO_0006914Biological processautophagy
GO_0010468Biological processregulation of gene expression
GO_0051865Biological processprotein autoubiquitination
GO_0005575Cellular componentcellular_component
GO_0005764Cellular componentlysosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTRIM17
Protein nameTripartite motif-containing 17, isoform CRA_b (cDNA FLJ30864 fis, clone FEBRA2004091, highly similar to Tripartite motif-containing protein 17)
E3 ubiquitin-protein ligase TRIM17 (EC 2.3.2.27) (RING finger protein 16) (RING-type E3 ubiquitin transferase TRIM17) (Testis RING finger protein) (Tripartite motif-containing protein 17)
Tripartite motif containing 17
SynonymsRBCC
hCG_42238
RNF16
TERF
DescriptionFUNCTION: E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation . Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation . Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 . Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death. In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities. Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (By similarity). Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 . .

AccessionsENST00000295033.7 [Q9Y577-1]
E5RJW6
ENST00000457345.2
B3KP04
J3KNZ3
ENST00000366698.7 [Q9Y577-1]
J3KQG0
Q9Y577
E5RI62
ENST00000355586.4
ENST00000456946.6 [Q9Y577-2]
ENST00000366697.6 [Q9Y577-1]
ENST00000479800.1
ENST00000520264.1