TRBC1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRBC1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRBC1 at tissue level.

III. Associated gene sets

GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0046631Biological processalpha-beta T cell activation
GO_0050852Biological processT cell receptor signaling pathway
GO_0042105Cellular componentalpha-beta T cell receptor complex
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane

IV. Literature review

[source]
Gene nameTRBC1
Protein nameT cell receptor beta constant 1
Synonyms
DescriptionFUNCTION: Constant region of T cell receptor (TR) beta chain . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity . .

AccessionsA0A5H1ZRT1
ENST00000632136.1
P01850
ENST00000633705.1