TRAFD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045824Biological processnegative regulation of innate immune response
GO_0005739Cellular componentmitochondrion
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRAFD1
Protein nameTRAF-type zinc finger domain-containing protein 1 (Protein FLN29)
Alternative protein TRAFD1
TRAF-type zinc finger domain containing 1
TRAF-type zinc finger domain-containing protein 1
SynonymsFLN29
DescriptionFUNCTION: Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). .

FUNCTION: Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3. .

FUNCTION: Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3. .

AccessionsENST00000257604.9 [O14545-1]
F8VVF3
ENST00000552890.5 [O14545-2]
ENST00000549358.5
O14545
L8E7W3
S4R2Z9
ENST00000548092.5
F8VNX8
F8VWK2
ENST00000412615.7 [O14545-1]
ENST00000547063.5
ENST00000552896.1