TPRXL report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TPRXL at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TPRXL at tissue level.

III. Associated gene sets

GO_0160021Biological processmaternal-to-zygotic transition of gene expression
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameTPRXL
Protein nameTetra-peptide repeat homeobox-like protein
Synonyms
DescriptionFUNCTION: Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization . Protein produced from maternal transcripts that binds and activates expression of key ZGA marker genes, such as NANOGNB, ZSCAN4, DUXB, KLF5 and DPPA3 . Binds to regulatory DNA sequences containing a 5'-TAATCC-3' sequence motif (By similarity). .

AccessionsQ17RH7