TPRX2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TPRX2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TPRX2 at tissue level.

III. Associated gene sets

GO_0160021Biological processmaternal-to-zygotic transition of gene expression
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0003677Molecular functionDNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameTPRX2
Protein nameTetrapeptide repeat homeobox 2
Tetrapeptide repeat homeobox protein 2
Synonyms
DescriptionFUNCTION: Transcription factor expressed after fertilization required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization . Binds and activates expression of key ZGA marker genes, such as NANOGNB, ZSCAN4, DUXB, KLF5 and DPPA3 . Binds to regulatory DNA sequences containing a 5'-TAATCC-3' sequence motif . .

AccessionsENST00000535362.3
P0DV77
A0A8V8TNP4
A0A8V8TPE6
ENST00000699059.1
ENST00000699383.1