TPPP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0014003Biological processoligodendrocyte development
GO_1904428Biological processnegative regulation of tubulin deacetylation
GO_0051301Biological processcell division
GO_0032288Biological processmyelin assembly
GO_0051418Biological processmicrotubule nucleation by microtubule organizing center
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0046785Biological processmicrotubule polymerization
GO_0048709Biological processoligodendrocyte differentiation
GO_0032273Biological processpositive regulation of protein polymerization
GO_0030953Biological processastral microtubule organization
GO_0070507Biological processregulation of microtubule cytoskeleton organization
GO_0031643Biological processpositive regulation of myelination
GO_0001578Biological processmicrotubule bundle formation
GO_0005874Cellular componentmicrotubule
GO_0072686Cellular componentmitotic spindle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005815Cellular componentmicrotubule organizing center
GO_0005794Cellular componentGolgi apparatus
GO_0097427Cellular componentmicrotubule bundle
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0150051Cellular componentpostsynaptic Golgi apparatus
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0015631Molecular functiontubulin binding
GO_0000287Molecular functionmagnesium ion binding
GO_0140490Molecular functionmicrotubule nucleator activity
GO_0008017Molecular functionmicrotubule binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameTPPP
Protein nameBrain-specific protein p25 alpha, isoform CRA_b (Fibroblast growth factor-2 repression protein-1) (Tubulin polymerization promoting protein) (cDNA FLJ30358 fis, clone BRACE2007749, highly similar to Tubulin polymerization-promoting protein)
Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha)
SynonymshCG_16469
TPPP1
FREP1
DescriptionFUNCTION: Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath . Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath . Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes . Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear . In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network . Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 . Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility . Plays a role in cell proliferation by regulating the G1/S-phase transition . Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 . .

AccessionsQ4L233
O94811
ENST00000360578.7