Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| conventional dendritic cell | 7 studies | 26% ± 10% | |
| epithelial cell | 6 studies | 32% ± 16% | |
| epithelial cell of proximal tubule | 5 studies | 29% ± 7% | |
| non-classical monocyte | 4 studies | 27% ± 9% | |
| macrophage | 4 studies | 26% ± 6% | |
| classical monocyte | 3 studies | 25% ± 4% | |
| GABAergic neuron | 3 studies | 20% ± 4% | |
| glutamatergic neuron | 3 studies | 31% ± 6% | |
| dendritic cell | 3 studies | 44% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 920.56 | 1444 / 1445 | 100% | 41.91 | 183 / 183 |
| thymus | 100% | 6389.07 | 653 / 653 | 100% | 134.44 | 604 / 605 |
| intestine | 100% | 1832.59 | 966 / 966 | 100% | 64.36 | 526 / 527 |
| stomach | 100% | 934.76 | 359 / 359 | 100% | 58.98 | 285 / 286 |
| brain | 100% | 1706.30 | 2639 / 2642 | 100% | 30.72 | 703 / 705 |
| prostate | 100% | 1195.10 | 244 / 245 | 100% | 40.30 | 502 / 502 |
| kidney | 100% | 4110.29 | 89 / 89 | 99% | 68.98 | 895 / 901 |
| lung | 99% | 1013.35 | 574 / 578 | 100% | 44.02 | 1155 / 1155 |
| breast | 100% | 790.20 | 458 / 459 | 99% | 43.16 | 1112 / 1118 |
| bladder | 100% | 873.71 | 21 / 21 | 99% | 43.23 | 500 / 504 |
| liver | 100% | 3175.65 | 226 / 226 | 99% | 52.36 | 402 / 406 |
| uterus | 100% | 862.24 | 170 / 170 | 98% | 37.36 | 452 / 459 |
| pancreas | 98% | 758.04 | 323 / 328 | 99% | 34.82 | 176 / 178 |
| skin | 100% | 1131.68 | 1803 / 1809 | 98% | 59.74 | 461 / 472 |
| ovary | 98% | 515.06 | 177 / 180 | 99% | 35.76 | 425 / 430 |
| adrenal gland | 100% | 2427.37 | 258 / 258 | 90% | 26.31 | 208 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 29.82 | 29 / 29 |
| spleen | 100% | 1092.76 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 21.27 | 1 / 1 |
| adipose | 99% | 707.90 | 1196 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 99% | 886.60 | 797 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 759.30 | 1325 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 35.40 | 44 / 45 |
| heart | 94% | 892.97 | 806 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 88% | 27.79 | 70 / 80 |
| peripheral blood | 82% | 642.21 | 765 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006139 | Biological process | nucleobase-containing compound metabolic process |
| GO_0042178 | Biological process | xenobiotic catabolic process |
| GO_0006805 | Biological process | xenobiotic metabolic process |
| GO_0032259 | Biological process | methylation |
| GO_0005829 | Cellular component | cytosol |
| GO_1904047 | Molecular function | S-adenosyl-L-methionine binding |
| GO_0008119 | Molecular function | thiopurine S-methyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TPMT |
| Protein name | Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) |
| Synonyms | |
| Description | FUNCTION: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor . TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. . |
| Accessions | P51580 Q9BS45 ENST00000309983.5 |
