TPCN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007040Biological processlysosome organization
GO_0006939Biological processsmooth muscle contraction
GO_0090117Biological processendosome to lysosome transport of low-density lipoprotein particle
GO_0019722Biological processcalcium-mediated signaling
GO_0034220Biological processmonoatomic ion transmembrane transport
GO_0017157Biological processregulation of exocytosis
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0048086Biological processnegative regulation of developmental pigmentation
GO_0051209Biological processrelease of sequestered calcium ion into cytosol
GO_0051452Biological processintracellular pH reduction
GO_0010506Biological processregulation of autophagy
GO_0019065Biological processreceptor-mediated endocytosis of virus by host cell
GO_0075509Biological processendocytosis involved in viral entry into host cell
GO_0033280Biological processresponse to vitamin D
GO_0035725Biological processsodium ion transmembrane transport
GO_0031902Cellular componentlate endosome membrane
GO_0034702Cellular componentmonoatomic ion channel complex
GO_0005764Cellular componentlysosome
GO_0033162Cellular componentmelanosome membrane
GO_0005829Cellular componentcytosol
GO_0010008Cellular componentendosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0036020Cellular componentendolysosome membrane
GO_0097682Molecular functionintracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity
GO_0072345Molecular functionNAADP-sensitive calcium-release channel activity
GO_0005248Molecular functionvoltage-gated sodium channel activity
GO_0015280Molecular functionligand-gated sodium channel activity
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0005245Molecular functionvoltage-gated calcium channel activity
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_0005515Molecular functionprotein binding
GO_0005262Molecular functioncalcium channel activity

IV. Literature review

[source]
Gene nameTPCN2
Protein nameTwo pore segment channel 2
Two pore channel protein 2 (Two pore calcium channel protein 2)
SynonymsTPC2
DescriptionFUNCTION: Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) . Localizes to the lysosomal and late endosome membranes where it regulates organellar membrane excitability, membrane trafficking, and pH homeostasis. Is associated with a plethora of physiological processes, including mTOR-dependent nutrient sensing, skin pigmentation and autophagy . Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 . As calcium channel, it increases the pH in the lysosomal lumen, as sodium channel, it promotes lysosomal exocytosis . Plays a crucial role in endolysosomal trafficking in the endolysosomal degradation pathway and is potentially involved in the homeostatic control of many macromolecules and cell metabolites (By similarity) . Also expressed in melanosomes of pigmented cells where mediates a Ca(2+) channel and/or PI(3,5)P2-activated melanosomal Na(+) channel to acidify pH and inhibit tyrosinase activity required for melanogenesis and pigmentation . Unlike the voltage-dependent TPCN1, TPCN2 is voltage independent and can be activated solely by PI(3,5)P2 binding. In contrast, PI(4,5)P2, PI(3,4)P2, PI(3)P and PI(5)P have no obvious effect on channel activation . .; FUNCTION: (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm. .; FUNCTION: (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC), by endocytosis. .

AccessionsENST00000294309.8
Q8NHX9
A0A1B0GTM1
ENST00000635811.1
A0A1B0GUM5
ENST00000637504.1
E7ETX0
ENST00000542467.1
ENST00000637342.1