TP53RK report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TP53RK at tissue level.

III. Associated gene sets

GO_0006468Biological processprotein phosphorylation
GO_0070525Biological processtRNA threonylcarbamoyladenosine metabolic process
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0008033Biological processtRNA processing
GO_0000408Cellular componentEKC/KEOPS complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0016787Molecular functionhydrolase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005515Molecular functionprotein binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0002039Molecular functionp53 binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameTP53RK
Protein nameEKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
SynonymsC20orf64
PRPK
DescriptionFUNCTION: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine . The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 . TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation . .

AccessionsQ5JZ02
ENST00000372102.3
ENST00000372114.4
Q96S44