TP53INP2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TP53INP2 at tissue level.

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0008104Biological processprotein localization
GO_0001894Biological processtissue homeostasis
GO_1903828Biological processnegative regulation of protein localization
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0000045Biological processautophagosome assembly
GO_0001649Biological processosteoblast differentiation
GO_0005829Cellular componentcytosol
GO_0031410Cellular componentcytoplasmic vesicle
GO_0016605Cellular componentPML body
GO_0005776Cellular componentautophagosome
GO_0005634Cellular componentnucleus
GO_0043130Molecular functionubiquitin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTP53INP2
Protein nameTumor protein p53-inducible nuclear protein 2 (Diabetes and obesity-regulated gene) (p53-inducible protein U) (PIG-U)
Tumor protein p53 inducible nuclear protein 2
SynonymsPINH
DOR
C20orf110
DescriptionFUNCTION: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. .

AccessionsQ5JX65
ENST00000414082.1
ENST00000374809.6
ENST00000451665.5
Q5JX66
Q8IXH6
ENST00000374810.8