TOMT report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TOMT at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TOMT at tissue level.

III. Associated gene sets

GO_0007605Biological processsensory perception of sound
GO_0042417Biological processdopamine metabolic process
GO_0032259Biological processmethylation
GO_0032502Biological processdevelopmental process
GO_0060117Biological processauditory receptor cell development
GO_0042424Biological processcatecholamine catabolic process
GO_0042420Biological processdopamine catabolic process
GO_0005575Cellular componentcellular_component
GO_0005783Cellular componentendoplasmic reticulum
GO_0005886Cellular componentplasma membrane
GO_0016206Molecular functioncatechol O-methyltransferase activity

IV. Literature review

[source]
Gene nameTOMT
Protein nameTransmembrane O-methyltransferase (EC 2.1.1.6) (Catechol O-methyltransferase 2) (Protein LRTOMT2)
catechol O-methyltransferase (EC 2.1.1.6) (Catechol O-methyltransferase 2)
SynonymsLRTOMT
PP7517
COMT2
DescriptionFUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function . Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (By similarity). .

AccessionsA0A2R8Y5M8
Q8WZ04
ENST00000541899.3