TNPO2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006606Biological processprotein import into nucleus
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008139Molecular functionnuclear localization sequence binding
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0061608Molecular functionnuclear import signal receptor activity

IV. Literature review

[source]
Gene nameTNPO2
Protein nameTNPO2 variant protein
Transportin-2 (Karyopherin beta-2b)
Transportin 2
TNPO2 protein
Alternative protein TNPO2
Synonymsprotein
variant
DescriptionFUNCTION: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). .

AccessionsK7ENW1
ENST00000356861.9 [O14787-2]
K7EMA3
ENST00000588216.5 [O14787-2]
O14787
K7ESJ3
K7ESG1
K7ELC3
ENST00000590781.1
L8ECE4
ENST00000589337.5
ENST00000589149.5
ENST00000587654.5
ENST00000425528.6 [O14787-1]
ENST00000586775.5
Q4LE60
A0A075B780
ENST00000585886.5
ENST00000588491.1
Q05D48
ENST00000592287.5 [O14787-1]
ENST00000450764.6 [O14787-2]
ENST00000589572.5
K7ESC1