TMTC4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0007605Biological processsensory perception of sound
GO_1905584Biological processouter hair cell apoptotic process
GO_0035269Biological processprotein O-linked mannosylation
GO_0032470Biological processpositive regulation of endoplasmic reticulum calcium ion concentration
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0004169Molecular functiondolichyl-phosphate-mannose-protein mannosyltransferase activity
GO_0000030Molecular functionmannosyltransferase activity
GO_0051117Molecular functionATPase binding

IV. Literature review

[source]
Gene nameTMTC4
Protein nameProtein O-mannosyl-transferase TMTC4 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 4) (Transmembrane and tetratricopeptide repeat-containing 4)
Transmembrane O-mannosyltransferase targeting cadherins 4
Synonyms
DescriptionFUNCTION: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. .

AccessionsENST00000342624.10 [Q5T4D3-3]
H7C095
ENST00000376234.7 [Q5T4D3-1]
C9K0R2
ENST00000423847.1
ENST00000328767.9 [Q5T4D3-4]
ENST00000440120.2
X6RF05
ENST00000475272.1
Q5T4D3