TMPRSS3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TMPRSS3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TMPRSS3 at tissue level.

III. Associated gene sets

GO_0007605Biological processsensory perception of sound
GO_0006883Biological processintracellular sodium ion homeostasis
GO_0006508Biological processproteolysis
GO_0005783Cellular componentendoplasmic reticulum
GO_0043025Cellular componentneuronal cell body
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0017080Molecular functionsodium channel regulator activity
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameTMPRSS3
Protein nameTransmembrane serine protease 3
Transmembrane protease serine 3 (EC 3.4.21.-) (Serine protease TADG-12) (Tumor-associated differentially-expressed gene 12 protein)
Transmembrane protease serine 3 (EC 3.4.21.-)
Transmembrane protease serine 3
SynonymsUNQ323/PRO382
TADG12
ECHOS1
DescriptionFUNCTION: Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). .

AccessionsENST00000398397.3 [P57727-3]
ENST00000652415.1 [P57727-5]
A0A140C6K2
A0A140C6K4
P57727
ENST00000644384.2 [P57727-5]
A0A140C6K1
A0A140C6K7
A0A140C6K3
A0A140C6K8
ENST00000433957.7 [P57727-1]
A0A140C6K0
ENST00000398405.5
B7WPR2
A0A140C6K5
A0A140C6K6