TMPRSS11D report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TMPRSS11D at tissue level.

III. Associated gene sets

GO_0006508Biological processproteolysis
GO_0007585Biological processrespiratory gaseous exchange by respiratory system
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0008233Molecular functionpeptidase activity
GO_0004252Molecular functionserine-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTMPRSS11D
Protein nameTransmembrane serine protease 11D
Transmembrane protease serine 11D (EC 3.4.21.-) (Airway trypsin-like protease) [Cleaved into: Transmembrane protease serine 11D non-catalytic chain; Transmembrane protease serine 11D catalytic chain]
SynonymsHAT
DescriptionFUNCTION: May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate. .

AccessionsO60235
H0Y8K7
ENST00000514868.1
ENST00000283916.11