TMEM53 | OmnibusX

Name	Number of supported studies	Average coverage
ciliated cell	4 studies	22% ± 3%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of TMEM53 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	643.88	258 / 258	100%	18.44	230 / 230
liver	100%	1579.05	226 / 226	100%	18.93	406 / 406
ovary	100%	594.48	180 / 180	100%	10.55	430 / 430
skin	100%	311.77	1806 / 1809	100%	13.55	472 / 472
brain	100%	466.19	2635 / 2642	100%	9.24	705 / 705
stomach	100%	420.44	358 / 359	100%	11.96	286 / 286
thymus	100%	468.43	653 / 653	100%	10.59	603 / 605
intestine	100%	560.31	965 / 966	100%	14.14	525 / 527
lung	99%	593.94	574 / 578	100%	10.66	1154 / 1155
bladder	100%	403.48	21 / 21	99%	12.61	500 / 504
prostate	100%	426.13	245 / 245	99%	9.11	498 / 502
kidney	100%	828.37	89 / 89	99%	7.62	893 / 901
uterus	100%	472.59	170 / 170	99%	8.62	454 / 459
breast	100%	647.25	459 / 459	99%	8.02	1105 / 1118
esophagus	100%	315.26	1443 / 1445	99%	7.24	181 / 183
pancreas	95%	248.32	313 / 328	100%	12.58	178 / 178
adipose	100%	676.35	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	18.04	80 / 80
lymph node	0%	0	0 / 0	100%	5.45	29 / 29
tonsil	0%	0	0 / 0	100%	6.15	45 / 45
ureter	0%	0	0 / 0	100%	17.54	1 / 1
blood vessel	100%	361.52	1333 / 1335	0%	0	0 / 0
spleen	100%	309.51	240 / 241	0%	0	0 / 0
heart	97%	486.11	837 / 861	0%	0	0 / 0
muscle	96%	235.85	769 / 803	0%	0	0 / 0
peripheral blood	73%	175.16	675 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0030279	Biological process	negative regulation of ossification
GO_0046822	Biological process	regulation of nucleocytoplasmic transport
GO_0030514	Biological process	negative regulation of BMP signaling pathway
GO_0045668	Biological process	negative regulation of osteoblast differentiation
GO_0031965	Cellular component	nuclear membrane
GO_0005640	Cellular component	nuclear outer membrane
GO_0005634	Cellular component	nucleus

Gene name	TMEM53
Protein name	Transmembrane protein 53 (Nuclear envelope transmembrane protein 4) Transmembrane protein 53
Synonyms	NET4
Description	FUNCTION: Ensures normal bone formation, through the negative regulation of bone morphogenetic protein (BMP) signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of phosphorylated SMAD1/5/9 proteins. .
Accessions	ENST00000372242.7 Q5TDE5 Q5TDE4 Q6P2H8 ENST00000372235.7 ENST00000372244.3 Q5TDE2 Q5TDE6 Q5TDE3 ENST00000372237.8 [Q6P2H8-1] ENST00000372243.7 ENST00000420706.1

TMEM53 report