TMEM175 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902600Biological processproton transmembrane transport
GO_0070050Biological processneuron cellular homeostasis
GO_0035751Biological processregulation of lysosomal lumen pH
GO_0090385Biological processphagosome-lysosome fusion
GO_0071805Biological processpotassium ion transmembrane transport
GO_0035752Biological processlysosomal lumen pH elevation
GO_0010008Cellular componentendosome membrane
GO_0005764Cellular componentlysosome
GO_0005768Cellular componentendosome
GO_0005765Cellular componentlysosomal membrane
GO_0005267Molecular functionpotassium channel activity
GO_0050544Molecular functionarachidonic acid binding
GO_0015252Molecular functionproton channel activity
GO_0022841Molecular functionpotassium ion leak channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTMEM175
Protein nameTransmembrane protein 175
Endosomal/lysosomal proton channel TMEM175 (Potassium channel TMEM175) (Transmembrane protein 175)
Endosomal/lysosomal proton channel TMEM175 (Potassium channel TMEM175) (Transmembrane protein 175) (hTMEM175)
SynonymsMGC4618
hCG_34455
DescriptionFUNCTION: Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH . Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis . Regulation of lumenal pH stability is required for autophagosome-lysosome fusion . Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes . Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors . The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation . The lysoK(GF) complex is required to protect neurons against stress-induced damage . .

AccessionsD6RAJ5
ENST00000514546.5
ENST00000515492.5
ENST00000264771.9 [Q9BSA9-1]
ENST00000514453.5
ENST00000507319.5
ENST00000622959.3 [Q9BSA9-2]
D6RHV8
ENST00000513682.5
ENST00000509508.5
F6UWG6
Q9BSA9
D6RDY8
ENST00000510493.5
ENST00000508204.5
ENST00000513952.5
D6RCD9
ENST00000515740.5 [Q9BSA9-2]
D6RIZ2
ENST00000504744.5
D6RBE5
D6RAU7
E7ETE6