I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 25% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 25% ± 5% |
Insufficient scRNA-seq data for expression of TMEM129 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 3313.74 | 226 / 226 | 100% | 51.97 | 406 / 406 |
| pancreas | 100% | 2815.63 | 328 / 328 | 100% | 64.17 | 178 / 178 |
| thymus | 100% | 5492.40 | 653 / 653 | 100% | 90.60 | 605 / 605 |
| brain | 100% | 3700.16 | 2640 / 2642 | 100% | 90.99 | 705 / 705 |
| kidney | 100% | 4775.17 | 89 / 89 | 100% | 74.76 | 898 / 901 |
| prostate | 100% | 4494.21 | 245 / 245 | 100% | 91.68 | 500 / 502 |
| skin | 100% | 2827.81 | 1807 / 1809 | 100% | 61.42 | 470 / 472 |
| adrenal gland | 100% | 4459.41 | 258 / 258 | 99% | 90.65 | 228 / 230 |
| uterus | 100% | 3968.25 | 170 / 170 | 99% | 49.94 | 455 / 459 |
| ovary | 100% | 3572.87 | 180 / 180 | 99% | 46.91 | 425 / 430 |
| intestine | 100% | 4519.65 | 966 / 966 | 99% | 57.65 | 520 / 527 |
| lung | 100% | 3247.88 | 577 / 578 | 99% | 44.74 | 1141 / 1155 |
| stomach | 100% | 3433.17 | 359 / 359 | 99% | 45.24 | 282 / 286 |
| breast | 100% | 3049.96 | 459 / 459 | 98% | 48.51 | 1101 / 1118 |
| bladder | 100% | 3775.43 | 21 / 21 | 98% | 59.66 | 496 / 504 |
| esophagus | 100% | 4073.82 | 1445 / 1445 | 98% | 33.21 | 179 / 183 |
| adipose | 100% | 2892.60 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 88.47 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 48.12 | 29 / 29 |
| spleen | 100% | 3775.89 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 46.13 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 61.25 | 1 / 1 |
| blood vessel | 100% | 3175.94 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 100% | 3331.82 | 860 / 861 | 0% | 0 | 0 / 0 |
| muscle | 100% | 2475.47 | 802 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 84% | 1401.77 | 785 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0006986 | Biological process | response to unfolded protein |
| GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
| GO_0030970 | Biological process | retrograde protein transport, ER to cytosol |
| GO_0000209 | Biological process | protein polyubiquitination |
| GO_0036503 | Biological process | ERAD pathway |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0061630 | Molecular function | ubiquitin protein ligase activity |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | TMEM129 |
| Protein name | E3 ubiquitin-protein ligase TM129 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TM129) Transmembrane protein 129, E3 ubiquitin ligase |
| Synonyms | |
| Description | FUNCTION: E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation. . |
| Accessions | ENST00000303277.6 [A0AVI4-2] H7C4I8 ENST00000480360.1 A0AVI4 H7C4G7 ENST00000382936.8 [A0AVI4-1] ENST00000460722.1 |
