TM4SF5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TM4SF5 at tissue level.

III. Associated gene sets

GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0005886Cellular componentplasma membrane
GO_0005765Cellular componentlysosomal membrane
GO_0016020Cellular componentmembrane
GO_0034618Molecular functionarginine binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTM4SF5
Protein nameTransmembrane 4 L6 family member 5 (Tetraspan transmembrane protein L6H)
TM4SF5 protein
Synonyms
DescriptionFUNCTION: Acts as a lysosomal membrane arginine sensor . Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations . Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus . CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression . .

AccessionsENST00000270560.4
Q6FHF6
O14894