TKFC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061624Biological processfructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
GO_0045088Biological processregulation of innate immune response
GO_0005975Biological processcarbohydrate metabolic process
GO_0046835Biological processcarbohydrate phosphorylation
GO_0019563Biological processglycerol catabolic process
GO_0039534Biological processnegative regulation of MDA-5 signaling pathway
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0034012Molecular functionFAD-AMP lyase (cyclizing) activity
GO_0050354Molecular functiontriokinase activity
GO_0005515Molecular functionprotein binding
GO_0004371Molecular functionglycerone kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameTKFC
Protein nameTriokinase and FMN cyclase
Triokinase/FMN cyclase (Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase) (Triokinase) (Triose kinase); FAD-AMP lyase (cyclizing) (EC 4.6.1.15) (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)]
DAK protein
Triokinase/FMN cyclase (EC 2.7.1.28) (EC 2.7.1.29) (EC 4.6.1.15) (Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing))
SynonymsDAK
DescriptionFUNCTION: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response . .

AccessionsE9PJG8
ENST00000534084.1
ENST00000524968.1
ENST00000394900.8 [Q3LXA3-1]
E9PQR1
A0AUP5
I3L252
Q3LXA3
ENST00000529479.5
H0YCY6
ENST00000532173.6