TJP3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TJP3 at tissue level.

III. Associated gene sets

GO_0090557Biological processestablishment of endothelial intestinal barrier
GO_0150105Biological processprotein localization to cell-cell junction
GO_1905605Biological processpositive regulation of blood-brain barrier permeability
GO_0098609Biological processcell-cell adhesion
GO_0035633Biological processmaintenance of blood-brain barrier
GO_0045216Biological processcell-cell junction organization
GO_0030054Cellular componentcell junction
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0005923Cellular componentbicellular tight junction
GO_0005634Cellular componentnucleus
GO_0050839Molecular functioncell adhesion molecule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTJP3
Protein nameTJP3 protein
Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3)
Tight junction protein 3
SynonymsZO3
DescriptionFUNCTION: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton . The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions . Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition . With TJP1 and TJP2, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity). .

AccessionsK7ESC0
ENST00000541714.7 [O95049-1]
K7EJ86
ENST00000539908.6 [O95049-5]
ENST00000586032.5
ENST00000590545.5
ENST00000589378.5 [O95049-4]
ENST00000587686.1 [O95049-3]
O95049
Q2VPE5