TIMM8A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TIMM8A at tissue level.

III. Associated gene sets

GO_0007399Biological processnervous system development
GO_0045039Biological processprotein insertion into mitochondrial inner membrane
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0042719Cellular componentmitochondrial intermembrane space protein transporter complex
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTIMM8A
Protein nameMitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1) (X-linked deafness dystonia protein)
Translocase of inner mitochondrial membrane 8A
SynonymsDDP1
TIM8A
DDP
DescriptionFUNCTION: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development. .

AccessionsENST00000645279.1
ENST00000644112.2
O60220
ENST00000372902.4
A0A2R8YDA8