TIMM21 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TIMM21 at tissue level.

III. Associated gene sets

GO_0030150Biological processprotein import into mitochondrial matrix
GO_0006886Biological processintracellular protein transport
GO_0033617Biological processmitochondrial cytochrome c oxidase assembly
GO_0032981Biological processmitochondrial respiratory chain complex I assembly
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005744Cellular componentTIM23 mitochondrial import inner membrane translocase complex
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameTIMM21
Protein nameMitochondrial import inner membrane translocase subunit Tim21 (TIM21-like protein, mitochondrial)
Mitochondrial import inner membrane translocase subunit Tim21
SynonymsTIM21
C18orf55
HSPC154
DescriptionFUNCTION: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. .

FUNCTION: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. .; FUNCTION: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. .

FUNCTION: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. .; FUNCTION: Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. .

AccessionsQ9BVV7
J3QRI1
ENST00000169551.11
ENST00000580087.5
J3KRJ3
ENST00000579071.1