TICRR report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TICRR at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TICRR at tissue level.

III. Associated gene sets

GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_0033314Biological processmitotic DNA replication checkpoint signaling
GO_0006281Biological processDNA repair
GO_0006260Biological processDNA replication
GO_0030174Biological processregulation of DNA-templated DNA replication initiation
GO_0010212Biological processresponse to ionizing radiation
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameTICRR
Protein nameTOPBP1 interacting checkpoint and replication regulator
Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein)
SynonymsC15orf42
DescriptionFUNCTION: Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. .

AccessionsH0YN97
Q7Z2Z1
ENST00000560985.5 [Q7Z2Z1-2]
ENST00000561095.1
ENST00000268138.12 [Q7Z2Z1-1]