Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 29% ± 10% | |
| glutamatergic neuron | 4 studies | 27% ± 7% | |
| ciliated cell | 3 studies | 24% ± 4% | |
| GABAergic neuron | 3 studies | 24% ± 3% | |
| dendritic cell | 3 studies | 22% ± 4% | |
| interneuron | 3 studies | 22% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 21% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 1387.14 | 21 / 21 | 100% | 20.07 | 504 / 504 |
| breast | 100% | 1352.97 | 459 / 459 | 100% | 27.26 | 1118 / 1118 |
| liver | 100% | 905.37 | 226 / 226 | 100% | 12.24 | 406 / 406 |
| stomach | 100% | 1037.43 | 359 / 359 | 100% | 18.04 | 286 / 286 |
| thymus | 100% | 1476.51 | 653 / 653 | 100% | 18.99 | 604 / 605 |
| intestine | 100% | 1338.47 | 966 / 966 | 100% | 18.84 | 526 / 527 |
| prostate | 100% | 1431.12 | 245 / 245 | 100% | 22.68 | 501 / 502 |
| kidney | 100% | 1114.90 | 89 / 89 | 100% | 14.23 | 899 / 901 |
| ovary | 100% | 1110.42 | 180 / 180 | 100% | 16.79 | 429 / 430 |
| brain | 100% | 1079.86 | 2634 / 2642 | 100% | 22.88 | 705 / 705 |
| adrenal gland | 100% | 1606.90 | 258 / 258 | 100% | 15.11 | 229 / 230 |
| uterus | 100% | 1244.58 | 170 / 170 | 100% | 17.51 | 457 / 459 |
| esophagus | 100% | 1276.50 | 1445 / 1445 | 99% | 16.51 | 182 / 183 |
| skin | 100% | 1728.95 | 1809 / 1809 | 99% | 20.97 | 468 / 472 |
| pancreas | 100% | 792.16 | 327 / 328 | 99% | 15.23 | 177 / 178 |
| lung | 99% | 1140.07 | 575 / 578 | 100% | 17.39 | 1150 / 1155 |
| adipose | 100% | 1283.11 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1189.35 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 17.10 | 29 / 29 |
| muscle | 100% | 1537.84 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1099.54 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 17.56 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 13.46 | 1 / 1 |
| heart | 97% | 1188.10 | 832 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 88% | 7.35 | 70 / 80 |
| peripheral blood | 77% | 835.38 | 712 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030488 | Biological process | tRNA methylation |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0016423 | Molecular function | tRNA (guanine) methyltransferase activity |
| GO_0000049 | Molecular function | tRNA binding |
| GO_0160117 | Molecular function | tRNA (guanine(6)-N2)-methyltransferase activity |
| GO_0160118 | Molecular function | tRNA (guanine(7)-N2)-methyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | THUMPD3 |
| Protein name | Alternative protein THUMPD3 THUMP domain containing 3 tRNA (guanine(6)-N2)-methyltransferase THUMP3 (EC 2.1.1.256) (THUMP domain-containing protein 3) |
| Synonyms | |
| Description | FUNCTION: Methyltransferase which catalyzes the formation of N(2)-methylguanosine at position 6 in a broad range of tRNA substrates containing the characteristic 3'-CCA terminus of mature tRNAs . Also catalyzes the formation of N(2)-methylguanosine at position 7 of tRNA(Trp) . Requires the methyltransferase adapter protein TRM112 for tRNA methyltransferase activity . . |
| Accessions | ENST00000419437.5 H7C0R6 ENST00000452837.7 C9JP31 ENST00000417036.1 C9J9V2 ENST00000345094.7 ENST00000515662.6 L8E880 ENST00000416603.1 ENST00000441127.5 H7C3J3 Q9BV44 |
