I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 23% ± 5% | |
| enterocyte | 4 studies | 25% ± 5% | |
| glutamatergic neuron | 3 studies | 27% ± 8% | |
| dendritic cell | 3 studies | 17% ± 0% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 23% ± 5% | |
| enterocyte | 4 studies | 25% ± 5% | |
| glutamatergic neuron | 3 studies | 27% ± 8% | |
| dendritic cell | 3 studies | 17% ± 0% |
Insufficient scRNA-seq data for expression of THOP1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2312.12 | 1445 / 1445 | 100% | 23.22 | 183 / 183 |
| brain | 100% | 4296.93 | 2640 / 2642 | 100% | 35.90 | 705 / 705 |
| uterus | 100% | 2561.21 | 170 / 170 | 100% | 28.77 | 458 / 459 |
| thymus | 100% | 2593.28 | 653 / 653 | 100% | 18.34 | 603 / 605 |
| intestine | 100% | 2353.92 | 966 / 966 | 99% | 31.35 | 524 / 527 |
| prostate | 100% | 4441.48 | 245 / 245 | 99% | 37.16 | 499 / 502 |
| skin | 100% | 2492.88 | 1808 / 1809 | 99% | 25.28 | 468 / 472 |
| stomach | 100% | 1486.85 | 358 / 359 | 99% | 26.50 | 284 / 286 |
| liver | 100% | 3159.74 | 226 / 226 | 99% | 22.49 | 400 / 406 |
| bladder | 100% | 2106.81 | 21 / 21 | 98% | 26.55 | 495 / 504 |
| adrenal gland | 100% | 1816.04 | 258 / 258 | 98% | 17.63 | 225 / 230 |
| kidney | 100% | 1889.72 | 89 / 89 | 97% | 11.80 | 878 / 901 |
| ovary | 100% | 2335.55 | 180 / 180 | 97% | 13.16 | 419 / 430 |
| breast | 100% | 1866.21 | 457 / 459 | 98% | 19.32 | 1093 / 1118 |
| lung | 99% | 1686.09 | 570 / 578 | 98% | 18.79 | 1133 / 1155 |
| pancreas | 95% | 1040.58 | 312 / 328 | 96% | 14.01 | 170 / 178 |
| eye | 0% | 0 | 0 / 0 | 100% | 17.22 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 47.14 | 29 / 29 |
| spleen | 100% | 2613.32 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 31.19 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 21.57 | 1 / 1 |
| muscle | 100% | 2277.09 | 801 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 1472.03 | 1326 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 99% | 1427.37 | 1194 / 1204 | 0% | 0 | 0 / 0 |
| heart | 97% | 2239.73 | 838 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 60% | 2050.37 | 555 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006518 | Biological process | peptide metabolic process |
| GO_0000209 | Biological process | protein polyubiquitination |
| GO_0006508 | Biological process | proteolysis |
| GO_0005758 | Cellular component | mitochondrial intermembrane space |
| GO_0005829 | Cellular component | cytosol |
| GO_0004222 | Molecular function | metalloendopeptidase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | THOP1 |
| Protein name | Thimet oligopeptidase (EC 3.4.24.15) Thimet oligopeptidase 1 Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78) |
| Synonyms | |
| Description | FUNCTION: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation . Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments . Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). . |
| Accessions | ENST00000591363.5 K7EIK4 K7EL02 K7EMU4 ENST00000585338.1 ENST00000587401.5 Q9BW75 K7EKB6 ENST00000307741.11 [P52888-1] K7EL32 ENST00000590970.5 Q96CV8 ENST00000587468.1 P52888 K7EP46 ENST00000586677.5 ENST00000395212.8 [P52888-2] |
