THEM5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of THEM5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of THEM5 at tissue level.

III. Associated gene sets

GO_0035965Biological processcardiolipin acyl-chain remodeling
GO_0006631Biological processfatty acid metabolic process
GO_0035336Biological processlong-chain fatty-acyl-CoA metabolic process
GO_0005759Cellular componentmitochondrial matrix
GO_0052816Molecular functionlong-chain fatty acyl-CoA hydrolase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTHEM5
Protein nameThioesterase superfamily member 5
Acyl-coenzyme A thioesterase THEM5 (Acyl-CoA thioesterase THEM5) (EC 3.1.2.2) (Acyl-coenzyme A thioesterase 15) (Thioesterase superfamily member 5)
SynonymsACOT15
DescriptionFUNCTION: Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters . Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin . Required for normal mitochondrial function . .

AccessionsH0Y6P4
ENST00000453881.2
ENST00000368817.10
Q8N1Q8