TEX14 | OmnibusX

Name	Number of supported studies	Average coverage
macrophage	3 studies	17% ± 1%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of TEX14 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	96%	65.96	441 / 459	36%	2.60	407 / 1118
brain	99%	90.82	2626 / 2642	10%	0.18	70 / 705
lung	99%	86.35	575 / 578	5%	0.12	54 / 1155
ovary	99%	79.62	178 / 180	5%	0.09	20 / 430
prostate	99%	87.31	243 / 245	4%	0.05	19 / 502
uterus	96%	49.72	163 / 170	5%	0.21	22 / 459
spleen	100%	85.85	241 / 241	0%	0	0 / 0
stomach	95%	39.21	341 / 359	3%	0.06	9 / 286
bladder	95%	26.10	20 / 21	2%	0.04	11 / 504
adrenal gland	93%	49.11	241 / 258	3%	0.05	7 / 230
skin	79%	86.14	1427 / 1809	17%	0.57	82 / 472
liver	94%	36.30	213 / 226	1%	0.02	4 / 406
blood vessel	95%	33.49	1265 / 1335	0%	0	0 / 0
adipose	93%	40.34	1124 / 1204	0%	0	0 / 0
intestine	92%	44.61	887 / 966	2%	0.02	8 / 527
esophagus	77%	25.87	1115 / 1445	3%	0.06	6 / 183
pancreas	79%	20.29	258 / 328	1%	0.01	1 / 178
thymus	78%	20.51	507 / 653	0%	0.01	1 / 605
heart	76%	22.46	658 / 861	0%	0	0 / 0
kidney	72%	24.25	64 / 89	1%	0.03	12 / 901
muscle	44%	10.96	355 / 803	0%	0	0 / 0
peripheral blood	41%	18.60	385 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	14%	0.91	4 / 29
tonsil	0%	0	0 / 0	2%	0.03	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0032466	Biological process	negative regulation of cytokinesis
GO_0008608	Biological process	attachment of spindle microtubules to kinetochore
GO_0051301	Biological process	cell division
GO_0007094	Biological process	mitotic spindle assembly checkpoint signaling
GO_0051306	Biological process	mitotic sister chromatid separation
GO_0043063	Biological process	intercellular bridge organization
GO_0007140	Biological process	male meiotic nuclear division
GO_0000776	Cellular component	kinetochore
GO_0030496	Cellular component	midbody
GO_0070062	Cellular component	extracellular exosome
GO_0045171	Cellular component	intercellular bridge
GO_0005737	Cellular component	cytoplasm
GO_0019901	Molecular function	protein kinase binding
GO_0005515	Molecular function	protein binding
GO_0005524	Molecular function	ATP binding
GO_0004672	Molecular function	protein kinase activity

Gene name	TEX14
Protein name	Testis expressed 14, intercellular bridge forming factor Inactive serine/threonine-protein kinase TEX14 (Protein kinase-like protein SgK307) (Sugen kinase 307) (Testis-expressed sequence 14) (Testis-expressed sequence 14 protein)
Synonyms	SGK307
Description	FUNCTION: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity). .
Accessions	J3QKU8 Q8IWB6 ENST00000581147.1 ENST00000240361.12 [Q8IWB6-1] ENST00000582740.1 ENST00000389934.7 [Q8IWB6-2] J3QLK3 ENST00000349033.10 [Q8IWB6-3]

TEX14 report